Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes.

We found that Tspo , Hsd3b , Cyp11a1, and Cyp17 showed decreasing trends in rats exposed to 0.1 mg/kg/day, with Hsd3b decrease reaching close to significance with a p -value of 0.0504 at dose 0.1, and a p -value of 0.0713 at dose 10 ( Figure 5 A).

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While the qPCR analysis showed a decreasing trend in Tspo for fetal exposure to the dose of 0.1 mg/kg/day, TSPO protein levels showed some decreases in testes of adult rats exposed in utero to both doses of Gen + DEHP mixtures ( Figure 5 B).

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