Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation.

In BA1-BA3 hydrogel preparations ( Figure 2 a), a decreasing trend in swelling ratio (31.72–20.18) at pH 7.4 was observed with the increase in crosslinker (MBA) contents ( p -value < 0.01).

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However, DLE% showed an increasing trend in the case of Ins-Mmt-BA4 to Ins-Mmt-BA6 hydrogel NCs, from 68.11% to 85.45% with a rise in maximum q from 27.02 to 52.34.

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Thus, a highly significant difference was shown between swelling of all formulations at pH 1.2 compared to pH 7.4.

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