Isavuconazole Pharmacokinetics and Pharmacodynamics in Children.

Further multivariate logistic regression analysis with forward/backward elimination to predict attributed mortality identified only average daily AUC ( p = 0.058) as a borderline significant predictor controlling for weight, age, trough concentration and dose.

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There was a highly significant linear relationship between average trough concentration > 5 mg/L and either higher average AST or ALT and a borderline association with average trough concentration > 5 mg/L and emergent hepatotoxicity on treatment.

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