One-way ANOVA showed a significant variability among the models ( F = 12.81; p < 0.0001; R 2 = 0.785), with highly significant differences between wild type mice and bank voles, as well as between wild type and some transgenic mouse lines, such as tg338, tg110, and tg361 ( Fig. 4 B ).
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An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein.
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