Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair.

Thus, we could see that when mice undergo I/R injury, the functional indicators of intestinal barrier damage (I-FABP and D-lactate) were significantly higher compared to those in the sham-operated group, and when I/R mice were given intraperitoneal injections of the Cth agonist MCH[ 37 ], there was a decreasing trend; in contrast, I-FABP and D-lactate were elevated when the mice were given intraperitoneal injections of the Cth inhibitor PAG [ 38 ] (Fig. 4 A).

also in 47,180 other papers