Neither tryptophan nor kynurenic acid were significantly altered between the 2 Ido1 genotypes in the setting of PKD, but we observed a possible trend toward decreased kynurenic acid levels at 6 months of age in Pkd1 RC/RC ; Ido1 –/– animals versus controls, which was more pronounced in males versus females ( Figure 2D and Supplemental Table 2 ).
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The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression.
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