A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency.

Front Immunol · 2022 · PMC9871622 · PMID 36703978

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( 34 ) demonstrated that patients with RTT showed a consistent and highly significant increase in the serum IgM fraction and we found that the expression of immunoglobulin-family genes in Mecp2 deficient meningeal immune cells ( Ighg2c, Igha, Ighg2b, Igkc , etc.) was abnormally high ( Figure 1 ).

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