Risk factors for primary Sjögren's Syndrome: a systematic review and meta-analysis.

There was significant heterogeneity ( I 2 = 64%, p = 0.1) so a random effects model was used, and the results revealed a marginally significant association between CGGGG Indel polymorphisms in the IRF5 gene and pSS, with a pooled OR and 95% CI of 1.69 (1.27, 2.24) ( z = 3.60, p = 0.0003, Fig. 3b ).

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