Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson's disease.

Despite these differences, δ age and δ PD showed a highly significant positive correlation (r = 0.71, p < 2.2 × 10 −16 , Pearson) ( Figure 4 C), suggesting that the process of decoupling is qualitatively similar and has a comparable genome-wide distribution in HA and PD, although it is more pronounced in the latter.

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