Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys.

This was also evident as a statistical trend of a shallower regression slope at 0.06- and 0.3-mg/kg doses of donepezil, which indicates less interference from distracting features when they were similar to the target ( Figure 2C ) (H 3 = 2.79, n.s.; slope changes relative to vehicle for 0.06-, 0.1-, and 0.3-mg/kg doses were 0.0357 ± 0.0236, −0.0289 ± 0.0334, and −0.0656 ± 0.0197, respectively).

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