High activation levels maintained in receptor-binding domain-specific memory B cells in people with severe coronavirus disease 2019.

In the case of the light chain, there was a nonsignificant trend over time where LV1 and LV7 usage increased and decreased over time, respectively (Supplementary figure 4g ) (LV1: P = 0.1563, LV7: P = 0.250), whereas LV2 and LV3 showed a significant increase and decrease, respectively, in their gene usage overtime (LV2: P = 0.0313, LV3: P = 0.0156).

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