GABA<sub>A</sub> receptor subtypes and benzodiazepine use, misuse, and abuse.

Front Psychiatry · 2022 · PMC9879605 · PMID 36713896

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failed to reach significanceno p-value reported

However, GABRA2 single nucleotide polymorphisms (SNPs) failed to reach significance on genome-wide association studies (GWAS) using more conservative analysis methods ( 185 , 186 ).

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highly significantno p-value reported

Thus, a highly significant question is whether GABAAR subtype-specific compounds, if developed, would have the same abuse and misuse liability as BDZs.

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