Co-delivery of gemcitabine and paclitaxel plus NanoCpG empowers chemoimmunotherapy of postoperative "cold" triple-negative breast cancer.

*p < 0.05 means significant difference, **p < 0.01, ***p < 0.001 and ****p < 0.0001 mean highly significant difference. 3 Results and discussion 3.1 Preparation of ATN-mG/P and mG/P The aim of this study is to tune “cold” TME in TNBC to “hot” therefore enabling efficient immunotherapy, for which we designed integrin-targeting micellar Gem and PTX (ATN-mG/P) to specifically co-deliver both drugs at predetermined ratio to TNBC cells.

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