In our study, we observed an increasing trend for acquisition of penicillin nonsusceptibility and cefotaxime resistance in quinolone-resistant CC4821 isolates, which further narrowed the choices for antimicrobial treatment and prophylaxis; safe and effective alternatives such as ceftriaxone, rifampin, and azithromycin could be considered to deal with this hyperinvasive lineage.
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Penicillin and Cefotaxime Resistance of Quinolone-Resistant Neisseria meningitidis Clonal Complex 4821, Shanghai, China, 1965-2020.
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