Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.

40 Mean TSH at month 13+ was increased (highly significant) from baseline in 14 patients in contrast to the observed changes during the first 9 months of treatment (statistically significant TSH increase). 40 Changes in total thyroxine/free thyroxine: TT4 was measured in 7 of 16 studies 30 , 33 , 35 , 36 , 37 , 38 , 39 and

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