Additionally, the majority of samples exhibit nuclear staining of the protein, and the proportion of FOXO3 protein down-regulation was significant with breast cancer III and IV stages, oestrogen receptor, tumour size, molecular subtype, and highly significant lymph node status ( Table 3 ; Figure 3 ). 3.3.
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FOXO3 gene hypermethylation and its marked downregulation in breast cancer cases: A study on female patients.
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