tended toward significancep = 0.056
However, there were considerably more patients who achieved a response (PR or CR) in group 1 than in groups 2 and 3 (82.86% vs 63.1%), and fewer patients with NR to treatment were in group 1 than in groups 2 and 3 (17.14% vs 36.9%), which tended toward significance ( p = 0.056).