Studies quantitating pO 2 in gliomas recorded a highly significant number of pO 2 readings in patients with GBM less than 2.5 mmHg ( 175 , 176 ), levels known to reduce the efficacy of radiotherapy where cellular sensitivity is halved when pO 2 is below 3 mmHg ( 177 ).
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Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia.
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