3D genome alterations in T cells associated with disease activity of systemic lupus erythematosus.

A decreasing trend of insulation strength was observed in the patients with SLE and indicated that SLE-associated inter-TADs loops were determined by weak insulation scores around TAD borders, and SLEDAI scores were involved in this trend ( figure 3E ). 10.1136/ard-2022-222653.supp2 Supplementary data 10.1136/ard

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Moreover, figure 1C shows an increasing trend of SLEDAI scores from right to left (PC1 from high to low) and from bottom to top (PC2 from low to high) at the TAD appearance level.

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