STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.

While the magnitudes of the increases in ORAI1 puncta number on cooling were variable in different cells (see data from individual cells in Fig 5B ), the averages from all cells showed a highly significant increase ( P < 0.01, blue line in Fig 5B ), followed by reversal on rewarming.

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