Preparation and characterization of doped hollow carbon spherical nanostructures with nickel and cobalt metals and their catalysis for the green synthesis of pyridopyrimidines.

As a result, the A (catalyst dose), B (temperature), C (time), A 2 , B 2 , C 2 , and BC (temperature × time) factors, with P -values smaller than 0.0500, were the highly significant factors in the increase of catalytic activity and the reaction yield in ethanol.

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