Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation.

In the text the authors describe results as "highly significant" and "marginally significant", please define what p-values it refers to, respectively. 7) Page 4, line 14-16: "The tentative conclusion from this observation is that the cleavage process, which may operate in multiple sites and sequentially on cleaved products, blurs any detailed correspondence between increase in content of a given fragment and disappearance of the full-size protein".

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The asymmetry was quantified by the ratio of signal densities, extranuclear (loosely called ‘cytosolic’)/nuclear, which in C2C12 myotubes was approximately threefold greater for GFP, a highly significant difference ( Table 2 ).

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