Among the lipid ratios, some showed a clear increasing trend [eg, (PE18:0/22:6)/LPE22:6] from the most severe group, S1, to the healthy group, while others showed either a decreasing trend [eg, (PC O-24:2/20:4)/LPC20:4] or did not show any clear trajectory [eg, (PE18:1/20:4)/LPE20:4].
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Phospholipid remodeling and its derivatives are associated with COVID-19 severity.
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The sentences
For unclear reasons, when the APACHE II value remained unchanged, the lipid ratio did not exhibit an obvious trend of change (patients 8 and 18), which could be the result of additional unknown underlying condition.
Interestingly, the changing patterns of phospholipid ratios in COVID-19 patients showed a decreasing trend in cluster I, an increasing trend in cluster II, and a mixed pattern in cluster III.