PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation.

Targeted assessment of DNA accessibility at monocyte and neutrophil-specific cCREs that correspond to enhancers, showed a highly significant reduction in chromatin accessibility ( P values: 3.52 × 10 −53 for URE HET Tet2 HET and 8.84 × 10 −26 for URE HET Tet2 KO ) in leukemic versus WT HPSCs, whereas single mutant HSPC showed no detectable differences ( Fig. 5B and C ; Supplementary Fig.

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