Barely Significant
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Germline homozygous missense DEPDC5 variants cause severe refractory early-onset epilepsy, macrocephaly and bilateral polymicrogyria.

Hum Mol Genet · 2023 · PMC9896472 · PMID 36067010

Europe PMCDOI
1
hedged sentence
0.0001
closest p · 0.0× alpha
0.0001
boldest claim

The sentences

highly significantP < 0.0001actually significant
By comparison, the two missense variants reported here were predicted to be substantially more destabilizing, and this difference was highly significant ( P < 0.0001, Student t-test).

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