<i>In silico</i> prediction of molecular mechanisms of toxicity mediated by the leptospiral PF07598 gene family-encoded virulence-modifying proteins.

Characteristic carbohydrate-binding aromatic patches and the presence of (QxW) 3 sequence motif support that VM proteins are bona fide R-type lectins Computational analysis and in vitro experimentation confirmed that only the RBL1 domain (N-terminal region of LA3490, 41 aa—150 aa) structurally superimposed with the ricin B chain (PBD; 2AAI-B: seven aa to 129 aa) with a highly significant RMSD value of 1.796.

also in 132,142 other papers