Stomach and duodenum dose-volume constraints for locally advanced pancreatic cancer patients treated in 15 fractions in combination with chemotherapy.

Front Oncol · 2022 · PMC9902495 · PMID 36761419

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

borderline significancep = 0.07so close (0.05 < p ≤ 0.1)

A borderline significance was found for duodenum D 0.03 (p = 0.07; OR = 1.19) for duodenal toxicity.

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of borderline significanceno p-value reported

Regarding the stomach, D 0.03 < 45 Gy and V44Gy < 2 cc may be suggested as sufficiently safe; however, V44Gy < 9 cc was found to be a robust constraint for duodenum, while the association with D 0.03 was found to be of borderline significance: despite that the best cutoff value suggested a threshold of 47.6 Gy, the lack of robustness seen at internal validation suggests a safer limit in the range 45–46 Gy as reasonable.

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