Macrophage differentiation is marked by increased abundance of the mRNA 3' end processing machinery, altered poly(A) site usage, and sensitivity to the level of CstF64.

2.3 Levels of cleavage/polyadenylation (C/P) complex proteins are upregulated at different times during monocyte-to-macrophage differentiation The analysis of the poly(A)-Click seq data described above shows that the APA occurring during monocyte-macrophage differentiation affected relevant functional categories of genes, and that similar numbers of genes showed shortening or lengthening in the 3’ UTR, with a slight trend towards shortening.

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3.2 The increase in C/P proteins may facilitate APA during macrophage differentiation Our study of the U937 and THP-1 monocytic cell lines shows that differentiating monocytic cells display an overall trend of increased expression of proteins of the core C/P machinery.

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