Tofacitinib as a maintenance therapy in patients with ulcerative colitis stratified by OCTAVE Sustain baseline Mayo endoscopic subscore.

This lack of statistical significance could at least in part be due to the small sample sizes, as a numerical trend was observed for most endpoints.

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When the proportion of patients achieving efficacy endpoints at Week 52 was stratified by change in MES from baseline to Week 8 of OCTAVE Induction 1 or 2, there was a slight trend for values to be numerically higher in patients who had a 2-point reduction in MES compared with those who had a 1-point reduction in MES.

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