Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance.

11 , 12 Many studies, including ours, have demonstrated that among the immune cells infiltrating the TME, tumor-associated macrophages (TAMs) are highly significant due to their comparatively high abundance and heterogeneous roles in facilitating tumor progression and drug resistance. 13 Moreover, recruitment and retention of disseminated TAMs is driven by tumor cells via various kinds of inflammatory factors, cytokines and pathogens, shifting TAM polarization

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