SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation.

Importantly, the benchmark NRF2 signature curated by Polonen and colleagues [ 42 ] revealed a highly significant enrichment in the SOCS1-low/SOCS3-high HCC group (NES = 1.4661141; p = 1 × 10 −4 ; p . adjusted = 5 × 10 −4 ) ( Figure 4 e).

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