Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition.

Combination treatment, however, induced highly significant increases in caspase 3/7 activation at 24 and 48 h time points compared to either DMSO vehicle control treatment or with either agent alone ( Figure 5 E). 2.6.

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