Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance.

In addition, to determine the presence of muscle atrophy, the cross-sectional area (CSA) of muscle fibers normalized to the number of fibers was measured, showing patients with DM had significantly lower CSA ( p = 0.007), while CSA in patients with IMNM showed a decreasing trend, although not significant, compared with controls ( Figure 2 c).

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