PCSK9 Inhibitors Have Apolipoprotein C-III-Related Anti-Inflammatory Activity, Assessed by 1H-NMR Glycoprotein Profile in Subjects at High or very High Cardiovascular Risk.

Int J Mol Sci · 2023 · PMC9917120 · PMID 36768645

Europe PMC DOI

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a nonsignificant trendno p-value reported

Changes in all Glyc signals were strongly and directly correlated with changes in triglycerides and apoC-III; GlycA and GlycF also correlated with changes in total VLDL particle concentrations (GlycB showed a nonsignificant trend).

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highly significantno p-value reported

In this context, we tested a set of biomarkers including hsCRP, GlycA, GlycB and GlycF and we observed a reduction of all glycoproteins; in particular, GlycA and GlycF showed a highly significant reduction of approximately 12% and 7%, respectively.

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