Hyperpolarized <sup>13</sup>C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts.

Int J Mol Sci · 2023 · PMC9917169 · PMID 36768822

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a decreasing trendp = 0.06so close (0.05 < p ≤ 0.1)

However, we observed a decreasing trend for LDH-A staining ( p = 0.06, n = 4), showing a potential role in the ratio of decreased lactate to pyruvate ( Figure 4 D).

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an increasing trendno p-value reported

At the same timepoint, the infiltration of T cells and macrophages showed an increasing trend in the anti-PD1 group at the edge of the tumors ( Figure 1 F).

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