Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease.

Brain · 2023 · PMC9924904 · PMID 35383826

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 3 × 10 −18actually significant

Investigation of the relationship between AD polygenic risk score (PRS) and plasma P-tau181 27 has revealed highly significant associations with PRS containing the APOE region ( P = 3 × 10 −18 −7 × 10 −15 ) and moderate association when APOE was excluded.

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