Genome-wide RNA polymerase stalling shapes the transcriptome during aging.

Nat Genet · 2023 · PMC9925383 · PMID 36658433

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highly significantno p-value reported

Notably, we found a highly significant overlap with the overall profiles of six independent studies representing downregulated mRNAs after UVC-induced DNA damage (Supplementary Table 1 ), further supporting the link between transcription-blocking DNA lesions and age-related transcriptional stress.

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