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Overexpression of adrenomedullin (ADM) alleviates the senescence of human dental pulp stem cells by regulating the miR-152/CCNA2 pathway.

Cell Cycle · 2023 · PMC9928452 · PMID 36310381

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a decreasing trendno p-value reported
The SOD and GSH-Px activities of both groups showed a decreasing trend from the 7th generation to the 15th generation, and the enzyme activity was significantly lower in the DPSC group than in the ADM-DPSC group ( P < 0.05). 3.5 Effect of ADM overexpression in DPSCs on the regulation of aging-related gene networks A comparison of the transcriptomes of the DPSC group and ADM-DPSC group cells at the 7-generation phase ( Figure 5a,b ) showed that 6545 genes were upregulated and 2198 genes were downregulated after overexpression of ADM.

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