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The impact of the rare disease and Orphan Drug Act in Taiwan.

J Food Drug Anal · 2021 · PMC9931014 · PMID 35649145

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an increasing trendno p-value reported
They also found an increasing trend of the related economic burden [ 39 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.