Delineating gene-environment effects using virtual twins of patients treated with clozapine.

But when modeled collectively using interaction terms, the combined effect of covariates may be significant. 1 , 2 Modeling approaches that quantify these interactions between variables across a target population may be used to optimize starting and continued dosing, an important consideration for model‐informed precision dosing (MIPD). 3 Physiologically‐based pharmacokinetic (PBPK) modeling is well‐suited for MIPD due to its highly mechanistic basis and the ability to consider concurrently the impact of patient, drug, and environmental variables on PKs.

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