Age was a borderline significant moderator of the effects of knee OA on CVD (p for interaction = 0.071), with the adverse interaction effect in younger over older (age < 65; HR 1.38, 95% CI 1.21–1.58; age ≥ 65: HR 1.17, 95% CI 1.03–1.32, respectively).
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Association between knee osteoarthritis and the risk of cardiovascular disease and the synergistic adverse effects of lack of exercise.
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