The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome.

Gene set enrichment analysis (GSEA) 45 showed a highly significant inverse correlation between the changes in gene expression elicited by ULK3 silencing and gene signatures related to poorly versus highly differentiated Head/Neck SCCs, HKCs with silencing of the ESR2 gene, a positive determinant of keratinocyte differentiation 46 , loss of TP53, and upregulation of the pro-tumorigenic TP63, Hh/GLI and MYC signaling pathways (Fig. 4b ).

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