highly significantP = 0.0003
Application of nicotinic PAM after xanomeline yielded a highly significant increase in peak amplitude (paired t -test, t 11 = 5.3, P = 0.0003; Fig. 5B ), charge transfer (paired t -test, t 11 = 4.7, P = 0.0007; Fig. 5C ) and rise speed (paired t -test, t 11 = 5.7, P = 0.0001; Fig. 5D ).