Surgery showed a favorable trend of ORR for BMs from NSCLC but did not reach a statistical difference (RR: 1.04, 95% CrI: 0.89–1.21, common effect model). 3.5 Heterogeneity, consistency, and sensitivity analysis There was low global heterogeneity for the comparison of radiotherapy-associated regiments (I2 = 0% for OS, I2 = 0% for CNS-PFS, and I2 = 8% for ORR) and low to moderate heterogeneity for the comparison of ICIs (I2 = 22% for OS, I2 = 33% for CNS-PFS, and I2 = 25% for ORR).
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Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis.
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