highly significantP =0.003
When we performed a bootstrap analysis with 10 000 repetitions of the difference in C statistics between the traditional risk factors and the model that included 5 metabolites together with the traditional risk factors, the mean difference across the subsamples was close to the calculation in the total sample, with a 95% CI being highly significant (bootstrapped mean C statistic difference between models 0.0391 [95% CI, 0.0134–0.0649]; P =0.003).