Murine model of elastase-induced proximal thoracic aortic aneurysm through a midline incision in the anterior neck.

Western blot results showed that the protein levels of Collagen III, Collagen I, MMP2, and MMP9 were also upregulated in the PTAA lesions ( Figure 5D ), quantitative gray-scale analysis showed that these genes had statistically significant elevation in protein levels except Collagen I, which only showed an increasing trend ( Figure 5E , P < 0.05 for Collagen III, MMP2, and MMP9, P = 0.11 for Collagen I), indicating upregulated collagen synthesis and enhanced extracellular matrix degradation in PTAA tissues.

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In the 5-min application group, the maximal aortic expansion occurred on postoperative day 7 (42.23 ± 3.92%), and a slight trend of regression in size was observed on day 28 (36.94 ± 5.30%).

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