In silico assessment on TdP risks of drug combinations under CiPA paradigm.

Sci Rep · 2023 · PMC9940090 · PMID 36807374

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a positive trendno p-value reported

The combined drugs (for both allotopic and syntopic models) show APD90 values in between with a positive trend (APD90 prolongation) as hydroxychloroquine, indicating combined drug’s effects on APD90 are more strongly influenced by hydroxychloroquine than diltiazem.

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