FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer.

We also determined FLI1, a transcription factor involved in development and cancer migration and invasion 44 , 45 , as the next best candidate enriched for MIBC-specific enhancers though its expression in MIBC cell lines and patients was borderline significant ( p -value = 0.1 for cell lines and p -value = 0.07 for tissue.) (Fig. 3a, b and Supplementary Fig. 6 ).

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