Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation.

Following LPS treatment in WT mice, there was a significant decrease in IL-10 expression of P1 cells and an almost significant reduction in that of P2 cells, with a significant decrease in MHC-II expression of P4 cells [Figure 4 A, 4B, 4E, 4F].

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However, the number of P4 cells decreased sharply in both models, with P2 and P3 cells exhibiting an increasing trend [Figure 1 ].

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On the contrary, it led to a decreasing trend in IL-1β expression of P1, P2, P3, and P4 cells and in MHC-II expression of P4 cells [Figure 4 C–4F].

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