Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.

Immunol Res · 2023 · PMC9945836 · PMID 36811819

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may be significantno p-value reported

Also, due to the large volume of distribution [ 39 ] and the high HCQ tissue concentrations as compared to plasma [ 41 , 42 ], immunosuppressive effects in specific tissues may be significant.

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